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Obese children had less gene methylation (gene not work as well) – March 2024

Alterations of DNA methylation profile in peripheral blood of children with simple obesity - March 2024

Health Inf Sci Syst. 2024 Mar 18;12(1):26. doi: 10.1007/s13755-024-00275-w
Yi Ren # 1 2 3, Peng Huang # 1 2, Xiaoyan Huang 4, Lu Zhang 1 2, Lingjuan Liu 1 2, Wei Xiang 5 6 7, Liqun Liu 1 2, Xiaojie He 1 8

Venn diagram which apparently shows differences in methylation
Image
Purpose: To investigate the association between DNA methylation and childhood simple obesity.

Methods: Genome-wide analysis of DNA methylation was conducted on peripheral blood samples from 41 children with simple obesity and 31 normal controls to identify differentially methylated sites (DMS). Subsequently, gene functional analysis of differentially methylated genes (DMGs) was carried out. After screening the characteristic DMGs based on specific conditions, the methylated levels of these DMS were evaluated and verified by pyrosequencing. Receiver operating characteristic (ROC) curve analysis assessed the predictive efficacy of corresponding DMGs. Finally, Pearson correlation analysis revealed the correlation between specific DMS and clinical data.

Results: The overall DNA methylation level in the obesity group was significantly lower than in normal. A total of 241 DMS were identified.
Functional pathway analysis revealed that DMGs were primarily involved in

  • lipid metabolism,
  • carbohydrate metabolism,
  • amino acid metabolism,
  • human diseases, among other pathways.

The characteristic DMS within the genes Transcription factor A mitochondrial (TFAM) and Piezo type mechanosensitive ion channel component 1(PIEZO1) were recognized as CpG-cg05831083 and CpG-cg14926485, respectively. Furthermore, the methylation level of CpG-cg05831083 significantly correlated with body mass index (BMI) and vitamin D.

Conclusions: Abnormal DNA methylation is closely related to childhood simple obesity. The altered methylation of CpG-cg05831083 and CpG-cg14926485 could potentially serve as biomarkers for childhood simple obesity.
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The more obese the child, the worse the Vitamin D genes: CYP27A1, CYP2R1 and CYP27B1 - March 2024

Decreased vitamin D bio-availability with altered DNA methylation of its metabolism genes in association with the metabolic disorders among the school-aged children with degree I, II and III obesity
The Journal of Nutritional Biochemistry https://doi.org/10.1016/j.jnutbio.2024.109627 PDF behind paywall
Xueyi Jiang 1 †, Lulu Xia 2 †, Tiantian Tang 1, Xiuqin Fan 1, Rui Wang 1, Meichen Wang 2, Wenli Yang 2, Jie Yan 2, Kemin Qi 1, Ping Li 1

Obesity is strongly associated with disturbances of vitamin D (VD) metabolites in the animal models. However, the related epidemiological evidence is still controversial, especially the different degrees of obesity. Hence, in this present representative cross-sectional study, 106 obesity school-age children aged 7-12 years were included and divided into different subgroups as degree I (the age- and sex-specific BMI≥95th percentile, n=45), II (BMI ≥120% percentile, n=34) and III (BMI ≥140% percentile, n=27) obesity groups across the ranges of body mass index (BMI).. While the age- and sex-matched subjects without obesity were as the control group. Notably, it was significantly different of body composition, anthropological and clinical characteristics among the above four subgroups with the dose-response relationships (P<0.05). Moreover, comparing with the control group, the serum VD concentrations were higher, VD metabolites like 25(OH)D, 25(OH)D3 and 1,25(OH)2D, and related hydroxylases as CYP27A1, CYP2R1 and CYP27B1 were lower in the degree I, II and III obesity subgroups (P<0.05), which were more disorder with the anthropological and clinical characteristics as the obesity was worsen in a BMI-independent manner (P<0.05).
However, there was a significant increase of CYP27B1 in the degree III obesity group than those in the degree I and II obesity subgroups. Furthermore, the methylation patterns on the genome-wide (Methylation/Hydroxymethylation) and VD metabolism genes (CYP27A1, CYP2R1 and CYP27B1) were negatively correlated with the worse obesity and their related expressions (P<0.05). In summary, these results indicated that obesity could affect the homeostasis of VD metabolism related genes such as CYP27A1, CYP2R1, CYP27B1 and etc through abnormal DNA methylation, resulting in the disorders of VD related metabolites to decrease VD bio-availability with the BMI-independent manner. In turn, the lower levels of VD metabolites would affect the liver function to exacerbate the progression of obesity, as the Degree II and III obesity subgroups.

Many of the 45 references are https://doi.org/10.1016/j.jnutbio.2024.109627 on-line

Vitamin D can methylate or activate many genes

5+ VitaminDWiki pages have METHYLATION in the title

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Items found: 5
196+ VitaminDWiki pages have ACTIVATION in the title

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Items found: 213
Title Modified
Dopamine quickly increased by Calcitriol (fully activated vitamin D) – might be a way to treat ADHD – Oct 2024 07 Nov, 2024
Lyme Disease and Vitamin D Receptor Activators 15 Oct, 2024
Multiple Sclerosis and Vitamin D Receptor Activators 15 Oct, 2024
Proofs that Vitamin D Receptor activation fights various diseases - many studies 21 Sep, 2024
Activated Vitamin D (calcitriol) injection speeds up orthodontic tooth movement (growth) – Aug 2024 30 Aug, 2024
Cows gave more milk after pregnancy if given Calcidiol (semi-activated Vitamin D) – RCT March 2021 03 Aug, 2024
Berberine: an antioxidant that activates the Vitamin D Receptor - many studies 03 Aug, 2024
Calcifediol (semi-activated vitamin D, Calcidiol) – Oct 2023 01 Aug, 2024
CBD improves the activation of 5 Vitamin D genes (in rats) – Dec 2023 24 Jul, 2024
Vitamin D can be activated in many tissues - no Kidney needed 23 Jul, 2024
Many cancers protect themselves by deactivating Vitamin D activated genes ( Pancreatic Cancer and HNF4A in this case) – April 2024 17 Jul, 2024
2260 diseases found to be fought by fully-activated Vitamin D (Calcitriol) – July 2024 10 Jul, 2024
Lung Cancer risk increases if low Vitamin D, poor activation of Vitamin D Receptor which affects the CALB1 gene – June 2024 29 Jun, 2024
Life extension by physical activity or more than 34 ng of Vitamin D – together they reduce aging by 1.3 years – July 2024 13 Jun, 2024
800 mg of Magnesium early in 3rd trimester significantly increased brain activity in preterm infants – RCT May 2024 03 Jun, 2024
Which Vitamin D Receptor activator for which health problem - Perplexity AI June 2024 02 Jun, 2024
Lumbar degenerative disc diseases might be fought by Vitamin D Receptor activation– many studies 28 May, 2024
The Vitamin D Receptor is activated by several Traditional Chinese Medicines – Jan 2024 23 May, 2024
Acupuncture of scalp activates Vitamin D genes CYP27a1, CYP27b1, and CYP24a (rats with strokes) – May 2024 23 May, 2024
Ulcerative Colitis associated with a 90% reduced activation of Vitamin D Receptor – May 2024 16 May, 2024
Autism treated by an activator of the Vitamin D Receptor: supforaphane - March 2024 02 Apr, 2024
Vitamin D Receptor activation by Traditional Chinese Medicine – Jan 2024 06 Feb, 2024
An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc. – Dec 2023 13 Jan, 2024
Obesity decreases BOTH Vitamin D levels and Vitamin D Receptor activation – Oct 2023 18 Oct, 2023
Activators of the Vitamin D Receptor include sulforaphane and curcumin – June 2020 19 Sep, 2023
T2 Diabetes might be fought by Vitamin D plus Vitamin D Receptor activators – April 2023 05 Jul, 2023
COVID in hospital stopped by Vitamin D Receptor activators (curcumin, quercetin) – RCT June 2023 25 Jun, 2023
Natural activators of the Vitamin D Receptor - some immune cells - April 2023 20 Jan, 2023
Less radiation-induced intestinal injury if activate the Vitamin D receptor (mice) – Dec 2022 29 Dec, 2022
Active vitamin D is related to COVID and Diabetes in 15 ways – Dec 2022 20 Dec, 2022
Brain cells can probably activate Vitamin D without liver or kidney (at least in rats) – Sept 2017 25 Oct, 2022
Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022 03 Oct, 2022
COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021 16 Aug, 2022
Calcifediol (semi-activated Vitamin D) might treat Respiratory Diseases such as COVID - July 2022 19 Jul, 2022
Calcitriol (activated Vitamin D) increases dementia (however, regular D decreases it) – June 2022 13 Jul, 2022
Calcitriol (active Vitamin D) prevents and treats COVID (with Chronic Kidney Disease in this case) June 2022 05 Jul, 2022
14th activator of the Vitamin D Receptor – Butyrate (from gut bacteria, or supplement) 01 Jul, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
Poor Vitamin D gene activation that results in rickets etc, (CYP27B1: 1 in 30 people in a region of Quebec) – May 2022 23 May, 2022
Immune system both activates and uses vitamin D (in brain, fight COVID, etc.) - March 2022 16 Mar, 2022
Parkinson’s Disease might be fought by Vitamin D and the activation of the Vitamin D Receptor – March 2022 14 Mar, 2022
Intense exercise increases vitamin D receptor activation 26 Dec, 2021
Many people are actively trying to lose weight gained during pandemic - Vitamin D will help 13 Dec, 2021
Macrophages (a white blood cell) can activate Vitamin D without the kidneys– Sept 2021 09 Oct, 2021
Fully-activated Vitamin D (Calcitriol) is produced inside and outside of the kidneys – July 2020 14 Sep, 2021
High-fat diet reduces CYP2R1 gene needed to make semi-activated vitamin D (mice) – Aug 2021 28 Aug, 2021
Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021 10 Jul, 2021
7X less likely to go to ICU if COVID-19 ward gave calcifediol (semi-activated Vitamin D) – July 2021 08 Jul, 2021
Diabetic eye wounds healed by topical activated Vitamin D (calcitriol, mice) – June 2021 19 Jun, 2021
Tiny amount of fully activated Vitamin D does treat psoriasis – Jan 2020 31 May, 2021
A tiny amount of Calcitiol (activated Vitamin D) for only 4 weeks does not help (sleep apnea in this case) – May 2021 31 May, 2021
COVID-19 activates and Vitamin D de-activates 12 cytokines (mini-review)– May 2021 29 May, 2021
Need 3X more Vitamin D (or take semi-activated vitamin D) if have poor gut – small RCT May 2021 26 May, 2021
Quercetin (a flavonoid) helps activate the Vitamin D receptor – many studies 24 May, 2021
Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020 23 May, 2021
Bone Mineral Density increased by Resveratrol (which activates the Vitamin D Receptor) – RCT Nov 2020 17 Feb, 2021
5X less likely to enter ICU with COVID-19 if get Calcifediol (semi-activated vitamin D) - RCT Feb 19, 2021 13 Feb, 2021
Weekly response to semi-activated vitamin D slightly better than standard – RCT Nov 2019 21 Jan, 2021
Active vitamin D (calcitriol) might fight COVID-19 – Jan 5, 2021 11 Jan, 2021
19X fewer COVID-19 infections if innate immune system activated – trial Oct 21, 2020 21 Nov, 2020
Semi-activated Vitamin D given weekly (used by Spanish COVID-19 trial) – US patent application Sept 2020 23 Sep, 2020
Mucosal membranes (mouth, lungs, nose, intestines, etc) can activate Vitamin D – July 2020 14 Sep, 2020
Centenarians in China 3X more likely to be active if high vitamin D – July 2020 09 Aug, 2020
Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020 04 Jul, 2020
Fructose reduces blood levels of active vitamin D 13 Jun, 2020
4X less of one chemo needed after vitamin D receptor activation - June 2020 02 Jun, 2020
Gene mutations which restrict Vitamin D activation (CYP27B1) results in many health problems – March 2020 22 Mar, 2020
Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020 22 Feb, 2020
Chicken bones, eggs, and activated vitamin D in eggs increased with 2 hours of daily UVB – Dec 2019 23 Dec, 2019
Autoimmune disease treated by Vitamin D, Zinc (and other activators of Vitamin D Receptor) – Oct 2019 17 Dec, 2019
Miraculous Physiological Activities of Vitamin D (30 to 100 ng) – Dec 2019 10 Dec, 2019
Fasting and Diabetes both reduce Vitamin D activation (CYP2R1 in rodents) – May 2019 19 Nov, 2019
Vitamin D Receptor in gut can be activated by lithocholic acid produced by gut bacteria 16 Nov, 2019
Active vitamin D levels can be temporarily raised 80 percent with Boron – US Patent Mar 2016 10 Nov, 2019
Cancer is leading cause of death - Vitamin D and Receptor activators help 09 Nov, 2019
Active muscles store vitamin D in the winter - Oct 2019 11 Oct, 2019
Hypothesis - Vitamin D is also activated, stored, and degraded in tissues (autacoid) – Sept 2019 05 Oct, 2019
Vitamin D Receptor - activation and deactivation- self-hacked June 2019 14 Jul, 2019
Obesity cut semi-activation of Vitamin D in half (mice) – Jan 2019 17 Jun, 2019
Best supplements for hay fever (Quercetin, which activates the Vitamin D receptor) - June 2019 05 Jun, 2019
Body may change gene activation if more Vitamin D is needed (Schizophrenia in this case) – Oct 2018 09 May, 2019
Crohn’s Disease Activity predicted by vitamin D plus 2 additional blood tests – Dec 2018 07 May, 2019
Curcumin may increase Vitamin D in tissues (activates Vitamin D Receptor) – Dec 2010 04 May, 2019
Autoimmune system, Dendric cells and active Vitamin D (technical) March 2019 16 Apr, 2019
Gums can activate Vitamin D locally (like most tissues) – Feb 2019 02 Mar, 2019
Progesterone activates vitamin D receptor - many studies 05 Feb, 2019
Some plants accumulate Vitamin D3 or active Vitamin D3 (calcitriol) – Dec 2018 26 Dec, 2018
Solanum glaucophyllum (a purple flower) produces active vitamin D3 26 Dec, 2018
Vitamin D Receptor in vitiligo skin activated by UVB – May 2018 11 Nov, 2018
How active vitamin D (Calcitriol) deals with cancer – June 2015 16 Aug, 2018
Active Vitamin D level should not be used for Prospective Studies of Cancer – Aug 2018 16 Aug, 2018
Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016 28 Jul, 2018
Colitis treated by activated vitamin D getting into the colon via emulsion (mice) – July 2018 24 Jul, 2018
Low vitamin D while Cystic Fibrosis is active – July 2018 20 Jul, 2018
Osteoporosis treatment by semi-activated (nutritional) Vitamin D – Sept 2018 13 Jul, 2018
Active vitamin D appears to treat cancer – more studies needed – June 2018 17 Jun, 2018
UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017 15 May, 2018
Vitamin D intervention -100 active clinical trials as of May 2018 30 Apr, 2018
Vitamin D receptor is activated somewhat by ginger, thyme, coriander, and lemongrass – March 2018 08 Apr, 2018
Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018 28 Mar, 2018
Hypothesis: Should test for unactivated Vitamin D, not activated – Feb 2018 27 Dec, 2017
Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017 22 Nov, 2017
Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene – Oct 2017 20 Nov, 2017
Cardiac Surgery and active vitamin D – quickly dropped by 29 percent, 6 more days in hospital if deficient – Nov 2017 20 Nov, 2017
Large amounts of curcumin might activate the Vitamin D receptor – Dec 2010 14 Nov, 2017
Off topic – Roundup found to be 125X more toxic than its active ingredient (glyphosate) - April 2014 25 Oct, 2017
Activated vitamin D (Calcitriol) substantially reduced elderly blood pressure in 6 weeks – Oct 2016 09 Oct, 2017
More than 5X increase in activation of scores of genes for women with Vitamin D (20,000 IU weekly) RCT Oct 2017 01 Oct, 2017
Semi-activated vitamin D (HyD3) successfully being used in human trials – RCT Sept 2017 22 Sep, 2017
Tricyclic antidepressants reduce the active but not the normally measured form of vitamin D in seniors – April 2014 15 Sep, 2017
Vitamin D Receptor Activator might help treat or prevent various diseases 27 Aug, 2017
Vitamin D Receptor activators (such as paricalcitol) treat dialysis patients similarly – Aug 2017 27 Aug, 2017
Active form of vitamin D directly protects the blood–brain barrier in multiple sclerosis – Aug 2017 26 Aug, 2017
UV light does not activate immunity genes, but Vitamin D supplements do – Feb 2017 05 Aug, 2017
Gene activation by high dose vitamin D - both quick and long term - April 2015 27 Jun, 2017
Less Pneumonia in those having more activated vitamin D (kidneys working)– April 2014 25 Jun, 2017
Liver transplant needs Vitamin D (actually semi-activated, not regular) – May 2017 27 May, 2017
Autoimmune diseases and over-active T cells (which are deactivated by vitamin D) – March 2014 11 May, 2017
Low active vitamin D increases chance of adult death by 50 percent in Japan – April 2017 23 Apr, 2017
Multiple sclerosis (relapsing-remitting) increases activation of Vitamin D Receptor by 6.6 X – March 2017 23 Apr, 2017
MSG induces weight gain in female rats not supplemented with active vitamin D – April 2017 15 Apr, 2017
Lungs with cystic fibrosis fail to activate vitamin D (poor CYP27B) – Feb 2016 10 Apr, 2017
Lung cells activate Vitamin D, without liver or kidney – Nov 2016 10 Apr, 2017
4X fewer malignancies after kidney transplant if got active vitamin D – Prospective Score Sept 2012 25 Mar, 2017
Sarcopenia: Nutrition and physical activity – systematic review – Jan 2017 10 Mar, 2017
Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016 27 Jan, 2017
Skin cancer (in mice) due to UV was prevented by vitamin D (active, topical) – June 2016 07 Jan, 2017
Kidney not essential for Vitamin D3 activation – fungi can do it – Jan 2014 24 Dec, 2016
Bones can activate vitamin D – July 2013 24 Dec, 2016
The eyes can also activate vitamin D – Feb 2014 24 Dec, 2016
Vitamin D being considered for Melanoma – active vitamin D is produced by skin – Nov 2016 01 Dec, 2016
The lungs can activate vitamin D locally – a Vitamin D inhaler might be possible – Nov 2016 20 Nov, 2016
Genes which regulate active vitamin D worsen with age – Oct 2016 31 Oct, 2016
Surprise:Three different types of vitamin D can activate the vitamin D receptor – Oct 2013 26 Oct, 2016
Vitamin D for kidney disease – use native or active form – Jan 2016 20 Oct, 2016
More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013 21 Sep, 2016
Skin can create and activate vitamin D – kidney not needed – July 2016 29 Jul, 2016
Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016 25 May, 2016
Dengue virus infection treated by (active) Vitamin D in the lab – April 2012 20 May, 2016
Infants getting 1600 IU vitamin D during first year were more active and leaner at age 3 – RCT Feb 2016 06 May, 2016
Fructose reduces levels of active vitamin D (not measured by standard tests) – April 2014 01 May, 2016
Calcitriol (active Vitamin D) recommended after kidney transplant – March 2014 28 Apr, 2016
Kidney disease helped by active or high dose Vitamin D - Feb 2014 28 Apr, 2016
Intestines do not process active vitamin D as well as you age – June 2012 09 Apr, 2016
Flame Retardants might also be active vitamin D retardants – Jan 2015 23 Feb, 2016
Get active vitamin D by eating Solanum Glaucophyllum leaves – Sept 2013 10 Feb, 2016
Rheumatoid arthritis recurrence reduced with active Vitamin D supplementation – Nov 2015 10 Dec, 2015
Outdoor activities prescribed by 20 French doctors to treat diseases associated with low vitamin D – Nov 2015 13 Nov, 2015
Diabetic Nephropathy – active vitamin D helps – Dec 2014 22 Oct, 2015
Magnesium reduced calcitriol (active vitamin D) artery calcification in CKD by 50 percent – Oct 2015 22 Oct, 2015
Vitamin D Receptors can be activated by other than Vitamin D - March 2015 18 Oct, 2015
Too much fructose reduced both serum and active vitamin D in rats – April 2013 12 Oct, 2015
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 03 Oct, 2015
Active Rheumatologic disease was 5X more likely with low vitamin D – June 2013 04 Sep, 2015
18X increased destruction of skin cancers if active vitamin D added to photodynamic therapy (mice) – March 2015 26 Jul, 2015
Time-release form of active vitamin D granted a patent for chronic kidney disease – July 2014 26 Jul, 2015
With CKD should measure the active form of vitamin D – April 2012 26 Jul, 2015
Active vitamin D treats Chronic Kidney Disease by stimulating Klotho production – Dec 2012 26 Jul, 2015
Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012 26 Jul, 2015
Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011 26 Jul, 2015
Not as much active vitamin D if poor kidney function and low vitamin D – March 2015 26 Jul, 2015
Active vitamin D associated with Metabolic Syndrome and LDL in colon cancer patients– March 2015 26 Jul, 2015
Active Vitamin D (Calcitriol) reference ranges, why too high is a problem– April 2015 26 Jul, 2015
Cancer treated better when active vitamin d (calcitriol) is inside of PLGA nanoparticles – June 2015 26 Jul, 2015
Fractures reduced 30 percent by Omega-3 (Omega-3 activates vitamin D) – May 2015 13 May, 2015
Children with active TB were 4.6X more likely to have low vitamin D – Dec 2014 06 May, 2015
Modified release active Vitamin D (calcifediol ) for those with poor Kidney function (USD 10,000 per year) – April 2015 17 Apr, 2015
Active vitamin D increased fractional rate of protein synthesis in chickens by 3X – March 2015 20 Mar, 2015
Active vitamin D levels vary by 72 percent during the day – March 2015 20 Mar, 2015
Active form of vitamin D appears to help prevent and treat some cancers – Feb 2011 16 Mar, 2015
Chronic pain in seniors associated with low levels of active, not measured vitamin D (strange)– Aug 2014 11 Mar, 2015
Wrong vitamin D test continues to be ordered - 66 percent of active Vit D tests were not wanted - March 2015 03 Mar, 2015
Blacks have lower vitamin D levels, but OK active vitamin D levels (VDBP) - Feb 2015 26 Feb, 2015
Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013 24 Feb, 2015
Active vitamin D decreased atrial fibrillation occurrence by 9X and duration by 77X (rabbits) – March 2014 13 Feb, 2015
Peritoneal Dialysis nicely treated by active vitamin D – July 2013 04 Feb, 2015
Flame Retardants somewhat reduce active levels of vitamin D – Jan 2015 18 Jan, 2015
Fructose reduces levels of active vitamin D in rats – April 2014 08 Jan, 2015
Metabolic Syndrome risk reduced 60 percent if high level of active vitamin D – Nov 2014 17 Dec, 2014
Cancer and active Vitamin D – in Spanish – Nov 2014 14 Nov, 2014
Inflammation, infection, active vitamin D, and Olmesartan - Sept 2014 03 Oct, 2014
Vitamin D and its active metabolites – DeLuca Jan 2014 14 Jul, 2014
Calcium intestinal absorption increased with active, but not tested level of vitamin D – May 2014 27 May, 2014
Retina can activate Vitamin D – April 2014 21 May, 2014
Vitamin D receptor activation and Chronic Kidney Disease – Oct 2011 14 May, 2014
Solanum glaucophyllum (a purple flower) produces active vitamin D 24 Feb, 2014
Application to FDA for use of active Vitamin D for hemodialysis patients – July 2011 18 Feb, 2014
Mice lacking CYP2R1 enzyme activate about half of much vitamin D – Sept 2013 17 Oct, 2013
RXRA gene activity at birth weakly associated with bone density at age 4 – Aug 2013 15 Aug, 2013
Pancreatic Cancer association with PRKCA gene and the active form of vitamin D – Nov 2012 10 Aug, 2013
Hypothesis: excess phosophorus lowers level of active vitamin D - May 2012 26 Jun, 2013
98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013 06 Jun, 2013
No indication of association with Prostate Cancer and retinol, vitamin E or active vitamin D – Nov 2012 25 May, 2013
Hypothesis – Receptor activation more important than vitamin D levels – June 2011 12 May, 2013
Perhaps even mitochondria can activate vitamin D – April 2013 01 May, 2013
Melanoma reduces by half the amount of vitamin D activated by the skin – March 2013 17 Apr, 2013
Activity and being outdoors helps seniors – GPS and Vitamin D Dec 2012 03 Apr, 2013
CYP27B1 gene decreases kidney production of active vitamin D – Feb 2013 24 Mar, 2013
Quantum dots should deliver active vitamin D directly to inflammatory breast cancer tumors – Feb 2013 17 Feb, 2013
Active Crohn's disease is associated with low vitamin D levels – Feb 2013 14 Feb, 2013
Breast cancer tissues in petri dish benefit from active but not inactive vitamin D – Oct 2012 07 Jan, 2013
Strong bones need both physical activity and vitamin D – Jan 2013 18 Dec, 2012
Active level of vitamin D are not indicated by standard blood tests - Sept 2012 10 Nov, 2012
Vitamin D can be activated in the skin – Sept 2011 09 Nov, 2012
Another activator of vitamin D is the skin - June 2011 09 Nov, 2012
PhD Dissertation - Local production of active vitamin D inhibits Prostate Cancer – Oct 2012 08 Nov, 2012
Low vitamin D in elderly women associated with being heavier and less active – Jan 2010 11 Oct, 2012
Osteoporosis medicine teriparatide increased active vitamin D by 25 pcnt– RCT June 2012 15 Sep, 2012
Review of Parkinson's disease and vitamin D recommends use of active form – Aug 2012 29 Aug, 2012
Petrie dish experiment confirms that active vitamin D reduces arterial inflammation – Aug 2012 23 Aug, 2012
Body tries to activate more vitamin D when it needs more Calcium from gut – Aug 2011 06 Nov, 2011
How active vitamin D stops various cancers – abstract Oct 2010 28 Sep, 2010
Less cancer if had more physical activity – perhaps due to the sun – Sept 2010 18 Sep, 2010

VitaminDWiki - 8 studies in both categories Genetics and Infant-Child

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VitaminDWiki - 17 Obesity and Vitamin D Receptor studies

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Obese children had less gene methylation (gene not work as well) – March 2024        
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